rTMS for Chronic Fatigue Syndrome: Where Neural Circuits Are Restored and Rewired · London

Chronic fatigue is neurological. The circuits driving it can be restored.


precision rTMS for chronic fatigue in london

At Naya Health, we use precision rTMS to restore and regulate the neural circuits underlying chronic fatigue

In conditions such as ME/CFS, post-viral fatigue and long COVID, persistent fatigue reflects a state of disruption deep in the brain’s regulatory systems: the pathways that govern effort, attention, autonomic function and recovery. These systems can become held in neural patterns that resist change long after the original trigger has resolved.

At Naya Health, we use precision rTMS to work gently and directly at those pathways, delivering targeted magnetic pulses to the prefrontal circuits involved in effort regulation, cognitive endurance and autonomic recovery. Non-invasive, drug-free, and guided by objective measurement throughout.

For those who have carried chronic fatigue without finding a way through, Naya offers something different: precision neuromodulation at the neural root. rTMS treatment for chronic fatigue, available at our London clinic.

Non-invasive, drug-free, and guided by objective measurement throughout.

For those who have lived with chronic pain or fibromyalgia without finding lasting relief, Naya offers something different: precision neuromodulation, rewiring the brain at its root.

we are a Precision rTMS clinic in London

A CFS Specialist Clinic Built on Precision rTMS · London

Naya Health is a precision neuromodulation clinic based in Marylebone, London. We work with patients experiencing persistent fatigue in the context of ME/CFS, post-viral fatigue, long COVID brain fog and chronic fatigue. Those who come to us have typically been screened for other physical causes. Where no physical cause of fatigue symptoms is present, persistent fatigue can indicate nervous system dysregulation at the neural level.

Your treatment is led by Dr Andy Franklyn-Miller, Chief Medical Officer, and Dr Greg Shields, Consultant Psychiatrist, alongside a specialist team of neuromodulation clinicians. Each protocol is personalised, mapped to your NayaScore™ baseline, and refined with care throughout your programme.

Chronic fatigue has a neurological root. The regulatory circuits driving it can be restored.

Your rTMS Treatment for Chronic Fatigue: What to Expect

Step 1: Initial Consultation and Assessment

Every treatment journey at Naya begins with a NayaScore™ assessment, an objective, multi-domain measure of your brain health and how it is currently functioning. For those living with chronic fatigue syndrome or post-viral fatigue, this gives us a precise picture of how your brain is currently regulating effort, attention and recovery, and forms the foundation from which your entire protocol is shaped.

Step 2: Your Personalised rTMS Programme

Based on your NayaScore™ baseline, your clinical team designs a precision rTMS programme specific to the pathways involved in your presentation. Sessions last around 30 minutes, and you remain comfortable and awake throughout with no anaesthesia or recovery time needed. Before each session, NayaState™ preparation primes your brain and nervous system to receive treatment, creating the optimal conditions for neuroplastic change.

Your protocol is custom-designed around your NayaScore™ baseline and guided by your biology at every stage. Given the sensitivity often present in chronic fatigue, your clinical team monitors your response carefully and refines the programme accordingly.

Step 3: Ongoing Measurement and Next Steps

NayaScore™ builds a clear, longitudinal picture of how your brain is restoring and recalibrating throughout your programme. At the close of treatment, your clinician reviews your outcomes with you and recommends a path forward. For many patients, neuroplastic change continues to consolidate long after the final session.

rTMS for Chronic Fatigue · London: HOW IT WORKS

Fatigue that persists is rarely simple. It reflects the brain held in neural patterns it cannot easily leave.

Precision rTMS works directly at those patterns.

In chronic fatigue syndrome and related conditions, the brain’s capacity to regulate effort, attention and recovery can become persistently disrupted following a physical or physiological stressor. The dorsolateral prefrontal cortex is central to this: the region that governs cognitive control, attention and autonomic regulation. When its activity is disturbed, the capacity to initiate, sustain and recover becomes consistently compromised.

TMS for chronic fatigue works at this level directly. Through gentle, repeated magnetic stimulation, it works to recalibrate activity at the neural root, supporting more adaptive responses to effort and more stable recovery over time. The aim is not to force activity, but to restore the brain’s own capacity to find its way back to regulation.

At Naya, target selection is guided by neurocardiac rTMS: measuring heart rate deceleration across multiple stimulation sites to identify the precise point of engagement for each individual’s frontal-vagal network. This level of personalisation matters particularly in chronic fatigue, where nervous system dysregulation is central to the condition and sensitivity to stimulation varies significantly between individuals.

rTMS for Chronic Fatigue: Precision Neuromodulation for Every Presentation

ME/CFS: persistent fatigue at the neural level

Myalgic encephalomyelitis and chronic fatigue syndrome involve debilitating fatigue, post-exertional malaise, unrefreshing sleep and cognitive difficulty. At their neurological core, these conditions involve nervous system dysregulation: the brain’s activity becomes locked into patterns that do not readily ease after physical or cognitive exertion.

Precision rTMS works at the prefrontal pathways involved in effort, attention and autonomic recovery. Emerging evidence, including a study by Miwa and Inoue (2023), supports rTMS as a well-tolerated intervention associated with meaningful reductions in fatigue severity in ME/CFS. Each protocol at Naya is personalised to your NayaScore™ baseline and refined throughout your chronic fatigue treatment at our London clinic.

Post-viral fatigue and long COVID brain fog

Post-viral fatigue and long COVID can produce a pattern of persistent brain fog, fatigue and disruption that shares significant overlap with ME/CFS. The underlying mechanism is likely neurological: viral illness can disturb the brain’s regulatory pathways in ways that persist long after the acute infection has resolved.

At Naya, precision rTMS works at the prefrontal pathways involved in cognitive regulation, attention and autonomic recovery, offering a clinically grounded approach to brain fog treatment in the context of long COVID and post-viral fatigue. NayaScore™ maps your cognitive and regulatory baseline precisely before treatment begins, tracking how your brain is restoring and rewiring across your programme.

Chronic fatigue without a clear diagnosis

For those living with persistent, disabling fatigue that has not resolved following appropriate medical investigation, and where no physical cause has been identified, rTMS may be a considered option. Where fatigue is accompanied by cognitive difficulty, sleep disruption and reduced tolerance for exertion, precision neuromodulation can work at the neural root of those patterns, within a carefully designed and individually monitored programme at our London clinic.

Chronic fatigue alongside fibromyalgia and depression

Chronic fatigue syndrome, fibromyalgia and depression frequently coexist, and the overlap is not coincidental. They share underlying neural circuits involved in pain processing, mood regulation, autonomic function and the regulation of effort and recovery. For many people, these conditions reinforce one another: fatigue deepens low mood, pain disrupts sleep, and depression lowers the threshold at which both are felt.

Naya’s precision neuromodulation approach works across these shared pathways, with each protocol personalised to your individual presentation. If you are experiencing fibromyalgia or depression alongside chronic fatigue, these can be addressed within the same treatment pathway. See also our dedicated pages on fibromyalgia and chronic pain and on depression for more on how Naya approaches each condition.

NAYASCORE™ IS PROPRIETARY TO NAYA HEALTH AND UNAVAILABLE AT ANY OTHER CLINIC

NayaScore™: Objective Measurement at Every Stage of Your Chronic Fatigue Treatment

Chronic fatigue is deeply individual in how it presents and how it shifts. NayaScore™ brings objective measurement to that picture, drawing on heart rate variability, cognitive function, metabolic markers and clinical assessment to build a precise baseline that reflects where your brain currently is, and what it needs.

Tracked throughout your chronic fatigue treatment in London, NayaScore™ gives you and your clinical team a clear, longitudinal view of how your brain is restoring and rewiring, what is changing beneath the surface, and where it is heading.

the role of precision rtms in treatment outcomes

NayaScore™: what objective measurement makes possible

1. Precision targeting.

Your rTMS protocol is mapped to the specific pathways involved in your presentation, ensuring stimulation is targeted and carefully calibrated to your individual neurology.

2. Objective evidence of change.

As your chronic fatigue treatment progresses, NayaScore™ tracks how your brain is restoring and recalibrating, giving you a clear, measurable picture of what is shifting across your programme.

3. A shared clinical picture.

Your NayaScore™ data is visible to your wider clinical team, whether that is your GP, specialist or therapist, creating a joined-up view of your brain health and treatment progress.

4. A foundation that builds.

NayaScore™ tracks your cognitive baseline across months and years, so that subtle changes are noticed early and responded to with care and precision.

The Evidence

The evidence base for rTMS in chronic fatigue syndrome is emerging. A 2025 pilot study by Corlier et al. evaluated dual-target rTMS in ME/CFS patients, with those completing the protocol demonstrating improvements across all five symptom domains including fatigue, pain, mood, sleep and cognition. As with all emerging fields, larger controlled studies are needed, and at Naya protocols are carefully tailored and monitored to individual tolerance throughout.

rTMS for Chronic fatigue:

rTMS for Chronic Fatigue: Safe, Gentle, and Well Tolerated

Precision care that is gentle on the nervous system

rTMS is extremely safe and one of the most well-tolerated approaches to chronic fatigue treatment available. For those with sensitised nervous systems, this is one of the most significant aspects of what precision neuromodulation offers. Sessions are non-invasive and require no recovery time. Where side effects occur, they are mild and transient, most commonly a mild headache or some fatigue on the night of treatment, easily addressed by adjusting session frequency.

The only clinically significant risk associated with rTMS is seizure, occurring in fewer than 0.0016% of treatments. It has never occurred at Naya Health. Thorough pre-treatment screening ensures any potential susceptibility is identified and addressed before treatment begins.

heart-brain coupling for personalised rtms

The heart-brain connection: personalised rTMS guided by your biology

The pathways that govern effort regulation, stress response and autonomic recovery are closely connected to cardiac function. In chronic fatigue syndrome and related conditions, autonomic disruption is frequently present, and the heart provides a measurable, accessible window into how these systems are operating.

At Naya, we use this connection to guide precision rTMS. By measuring heart rate response across multiple stimulation sites, we identify the precise target that most effectively engages each individual’s frontal-vagal pathway. In chronic fatigue, where individual sensitivity varies significantly, this level of personalisation is particularly meaningful.

Naya is currently the only clinic in the UK offering neurocardiac-guided rTMS.

To learn more, visit our dedicated heart-brain coupling page.

FAQ

How effective is rTMS for chronic pain and chronic fatigue syndrome?

rTMS has a growing evidence base for chronic pain and chronic fatigue syndrome. In conditions like fibromyalgia and central sensitisation, trials show meaningful pain reduction after 10–20 sessions, with effects sustained through neuroplasticity. For CFS and Long Covid fatigue, rTMS targets prefrontal circuits linked to energy and cognition, improving fatigue, brain fog, and mood. Early data at Naya show over 90% of patients experience improvement, compared to around 40% in standard care, though results vary and are not guaranteed.

Can rTMS help if my scans are normal but I still have pain or fatigue?

Yes. Normal scan results do not mean your pain or fatigue is not real; they mean it is neurological rather than structural. Chronic pain and chronic fatigue that cannot be explained by structural damage are typically driven by central sensitisation, dysregulated neural circuits, and disrupted brain network communication. rTMS works at this neurological level, targeting the brain regions and circuits that generate and maintain the symptoms.

How does rTMS treat pain at the neurological level?

Chronic pain often isn't about damaged tissue; it's about a brain that's gotten stuck. There's a region responsible for moderating pain signals that becomes underactive over time, leaving pain to run unchecked. rTMS uses gentle magnetic pulses to stimulate that region back into doing its job, not masking the pain, but addressing the neurological pattern keeping it in place. And because the brain is genuinely changeable, those new patterns keep developing long after treatment ends. For many people, the relief continues to grow.

How effective is rTMS for depression, anxiety, chronic pain, and fatigue?

One of the things that makes rTMS quietly remarkable is how many different conditions it can reach and why that actually makes sense. Depression, anxiety, chronic pain, and chronic fatigue; all of them feel like very different experiences to live with. But beneath the surface, they often share something: a brain whose regulatory systems have gone offline, whose networks have stopped communicating the way they should. rTMS works at exactly that level. Which is why the same treatment, carefully personalised, can make a meaningful difference across all conditions. At Naya, early outcomes across all four presentations have been significantly above what standard care typically produces, something we believe comes down to the precision of our approach.

Can rTMS reduce anxiety as well as low mood and chronic pain?

Yes. The neural circuits implicated in anxiety, low mood, and chronic pain overlap significantly, and they all involve dysregulation of prefrontal control over limbic and pain-processing networks. rTMS protocols can be targeted to address anxiety (through modulation of hyperactive fear circuits) and low mood (through activation of underactive motivational and reward networks) in the same treatment course.

Is rTMS a temporary fix, or can it lead to long-term remission?

rTMS produces lasting changes through neuroplasticity. This is not temporary symptom relief. For many patients, the improvements initiated by an rTMS course continue to develop and consolidate in the weeks and months following treatment as the brain reinforces its new patterns. Recurrence can occur in some patients, particularly under high stress or after significant life events, and maintenance treatment is available.

How does magnetic stimulation therapy actually work in the brain?

A TMS coil placed on the scalp delivers focused magnetic pulses that induce small electrical currents in targeted brain regions. These currents modulate neural activity, increasing underactive circuits or reducing overactive ones. With repeated sessions, this drives neuroplasticity, allowing more stable, regulated patterns to form. The treatment is non-invasive, requires no anaesthesia, and patients remain awake and comfortable. Because stimulation is localised, there are no systemic side effects.

What is the difference between rTMS for chronic fatigue and standard fatigue treatment?

Most fatigue treatment starts with the question: how do we help you manage this? Pacing, graded exercise, CBT, medication: these can all offer something, and for some people, they help. But they work around the fatigue, not with what's causing it at a neurological level. rTMS starts with a different question: what's actually happening in your brain? Chronic fatigue is often rooted in disrupted prefrontal networks, the circuits responsible for energy, arousal, and the feeling of being able to engage with life. When these go quiet, no amount of pacing or positive thinking can fully compensate. rTMS works by gently restoring activity in exactly those networks, helping your brain find its way back to patterns it's lost. At Naya, the NeuroScore™ assessment means we understand your specific neural profile before treatment begins, so what you receive isn't a standard fatigue protocol, but something built around what your brain actually needs. For people who've spent years being told to do less and rest more, that distinction can feel like someone finally asking the right question.

Can I get rTMS for chronic fatigue on the NHS?

rTMS for chronic fatigue syndrome is not currently available on the NHS. NHS provision of rTMS is limited to treatment-resistant depression in specific clinical settings. Naya Health is a private clinic, and all treatment is self-funded or through private medical insurance. Private medical insurance recognition for Naya's services is in progress. For patients who have exhausted NHS pathways for chronic fatigue, including those with Long Covid, Naya offers a private route to evidence-based neurological treatment that is not currently accessible through public health channels.

Is rTMS safe for people with chronic pain who have tried many treatments?

Yes. rTMS is non-invasive, drug-free, and has no systemic side effects, making it suitable for patients who have tried other treatments. Contraindications include certain implanted metal devices and a history of seizures, which are assessed beforehand. For most chronic pain and fatigue patients, rTMS is safe and well-tolerated, with the most common sensation being mild tapping at the treatment site.